Deep space exploration requires a paradigm shift in astronaut medical support toward Earth-independent medical operations. Currently, astronauts rely on real-time communications with ground-based medical facilities. However, as the distance from Earth increases, communication delays and disruptions increase. Crews engaged in deep space exploration will need to autonomously detect, diagnose, treat, and prevent diseases. One potential solution is to enhance the knowledge, skills, and capabilities of crews participating in long-duration exploration missions with a digital clinical decision support system (CDSS).